Cardiovascular and Venous Thromboembolism Disease in Patients with Von Willebrand Disease in the French West

Recruiting now

Conditions studied: Von Willebrand Diseases

In brief

Due to increasing of life expectancy, patients with von Willebrand disease are exposed to age-related pathologies such as cancer or cardiovascular diseases. Management of thrombotic events is challenging given the inherent bleeding risk in von Willebrand disease. Few data are currently available in the literature. The aim of the study is to describe the frequency and nature of arterial and venous thromboembolic events and atrial fibrillation in patients with von Willebrand disease in the West of France. The investigators will perform a retrospective multicenter study conducted in the von Willebrand population of the French West. Von Willebrand adult patients followed in one of the French West medical centers participating in the study, who presented deep vein thrombosis, pulmonary embolism, ischemic stroke, transient ischemic attack, acute coronary syndrome, acute limb ischemia, atrial fibrillation, arteriopathy of the lower limbs, angina will be eligible.

Key facts

Study ID

NCT05773638

Run by

University Hospital, Brest

People needed

100

Starts

2021-12-26

Expected to finish

2026-12-26

Last updated by the study team

2025-02-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Von Willebrand disease
• Adult
• Followed-up in a reference center of West of France (Caen, Brest, Nantes, Rennes, Le Mans, Angers)
• Consented to be included in BERHLINGO database
• Have presented a thrombotic and/or embolic event or cardiovascular disease including deep vein thrombosis, pulmonary embolism, ischemic stroke, transient ischemic attack, acute coronary syndrome, acute limb ischemia or angina or obliterating arteriopathy of the lower limbs, atrial fibrillation.
• Have not expressed their opposition

You may not qualify if…

• - Expression of opposition
• Acquired von Willebrand syndrome
• Patients under legal protection
• Minor

Where it is running

• CHU de Brest — Brest, France (enrolling)
• CHU d'Angers — Angers, France
• CHU de Caen — Caen, France
• CH le MANS — Le Mans, France
• CHU de Nantes — Nantes, France
• CHU de Rennes — Rennes, France

Full record on ClinicalTrials.gov

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