A Study of NT 201 Doses in the Treatment of Platysma Prominence

Completed · Phase 2 · Has a placebo group

Conditions studied: Platysma Prominence

In brief

The purpose of this study is to assess the safety and efficacy of NT 201 in adults with moderate to severe platysma prominence.

Key facts

Study ID

NCT05773053

Run by

Merz Aesthetics GmbH

People needed

73

Starts

2023-03-22

Expected to finish

2024-01-24

Last updated by the study team

2024-10-21

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Presence of four (medial and lateral, left and right) prominent platysmal bands
• Moderate to severe platysmal bands as assessed by the investigator and subject on the MAPS-D at maximum contraction

You may not qualify if…

• Any serious disease or disorder (medical or psychiatric) that could interfere with the safe completion of treatment or compromise subject safety
• Botulinum toxin treatment in the face (below the lower orbital rim), neck, or chest within the last 12 months prior to study treatment
• History of lower face surgery, neck or chest surgery, aesthetic procedures (e.g., ablative skin resurfacing, laser, chemical peel, micro-focused ultrasound, deoxycholic acid injections, micro-needling, non-surgical fat reduction procedure), and orthodontic procedures (e.g., braces) in the 12 months prior to study treatment
• Previous use of any permanent (non-biodegradable) or semi-permanent (e.g., calcium hydroxylapatite, poly-L-lactic acid, polymethyl methacrylate, etc.) facial tissue augmentation therapy, lifting sutures, permanent implants or autologous fat to the lower face (i.e., below the level of the bottom of the nose), neck, or chest within 24 months prior to study treatment
• Previous use of any hyaluronic acid based or collagen based biodegradable facial tissue augmentation therapy to the lower face (i.e., below the level of the bottom of the nose), neck, or chest within 12 months prior to study treatment
• Any medical condition that may put the subject at increased risk with exposure to botulinum toxin of any serotype, including myasthenia gravis, Lambert-Eaton-Syndrome, amyotrophic lateral sclerosis, or any other disorder that might interfere with neuromuscular function
• Female of childbearing potential not using a highly effective method of birth control, planning to get pregnant, or pregnant or lactating

Where it is running

• Merz Investigation Site #0010170 — Washington D.C., District of Columbia, United States
• Merz Investigational Site #0010453 — Aventura, Florida, United States
• Merz Investigation Site #0010470 — Coral Gables, Florida, United States
• Merz Investigation Site #0010105 — Metairie, Louisiana, United States
• Merz Investigation Site #0010471 — Verona, New Jersey, United States
• Merz Investigation Site #0010469 — New York, New York, United States
• Merz Investigation Site #0010405 — New York, New York, United States

Full record on ClinicalTrials.gov

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