Acute Myeloid Leukemia At Initial Diagnosis and/or Relapse in Children, Teenagers and Young Adults: Molecular Profiling, Multidrug Testing and MSC Interaction Studies
Recruiting now
Conditions studied: Acute Myeloid Leukemia, Genetic Predisposition to Disease
In brief
Pediatric acute myeloid leukemias are disease with poor prognosis (overall survival of 60-75%) and high relapse rate of 35-45% require further understanding of the underlying biological mechanisms. The main objective of this study is to establish a biological collection to evaluate the genomic profiling of leukemic cells from primary blasts at diagnosis and/or relapse to improve identification of the main genetic hits involved in resistance and could predict a high risk of relapse. Other objectives include the study of bone marrow mesenchymal stem cells and ex vivo drug testing.
Key facts
- Study ID
- NCT05772559
- Run by
- Assistance Publique - Hôpitaux de Paris
- People needed
- 500
- Starts
- 2023-05-31
- Expected to finish
- 2033-05-31
- Last updated by the study team
- 2024-06-26
Who can join
Age: any, up to 25. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 0-25 years old
- Newly diagnosed de novo or secondary Acute Myeloid Leukemia (AML) or
- Relapsed or refractory AML or
- Patients with genetic predisposition to develop AML or
- Patients without haematological malignancy nor AML genetic predisposition syndrome who undergo bone marrow aspirate as part of standard of care
- Signed informed consent of parents for patients aged less than 18 years old or signed informed consent of the patient for patients aged 18 and over.
You may not qualify if…
- Refuse to participate
- Chronic myeloid leukemia (CML)
- Lack of health insurance (French social security)
- Under protection (tutelle, curatelle or sauvegarde de justice)
- Pregnancy or breastfeeding
Where it is running
- CHU Amiens Picardie site Sud — Amiens, France (enrolling)
- CHU Angers — Angers, France (enrolling)
- Hopital Minjoz — Besançon, France (enrolling)
- CHU Pellegrin — Bordeaux, France (enrolling)
- CHRU Morvan — Brest, France (enrolling)
- CHU Caen — Caen, France (enrolling)
- CHU Estaing — Clermont-Ferrand, France (enrolling)
- CHU Francois Mitterand — Dijon, France (enrolling)
- CHU Grenoble — Grenoble, France (enrolling)
- CHU de la Réunion — La Réunion, France (enrolling)
- Hopital Jeanne de Flandre - CHRU — Lille, France (enrolling)
- CHU Limoges — Limoges, France (enrolling)
- HCL Lyon — Lyon, France (enrolling)
- Hôpital d'Enfants de la Timone — Marseille, France (enrolling)
- CHU Montpellier — Montpellier, France (enrolling)
- CHRU Nancy- Hopitaux de Brabois — Nancy, France (enrolling)
- CHU Nantes — Nantes, France (enrolling)
- CHU Nice — Nice, France (enrolling)
- Hopital Robert Debré — Paris, France (enrolling)
- Hopital Trousseau — Paris, France (enrolling)
- CHU Poitiers — Poitiers, France (enrolling)
- Hopital Américain — Reims, France (enrolling)
- CHU Hopital Sud — Rennes, France (enrolling)
- CHU Rouen — Rouen, France (enrolling)
- CHU Saint Etienne — Saint-Etienne, France (enrolling)
Full record on ClinicalTrials.gov
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