Assessing and Improving the Durability of Compensatory Cognitive Training for Older Veterans

Enrolling by invitation · Not applicable

Conditions studied: Mild Cognitive Impairment

In brief

Veterans have numerous risk factors (e.g., Post-traumatic stress disorder (PTSD), traumatic brain injury (TBI), cerebrovascular problems) for later-life cognitive and functional decline. Evidence supports the effectiveness of strategy-based cognitive rehabilitation therapies, including compensatory cognitive training (CCT), for such decline. However, questions remain about the length of time that CCT-driven improvements in cognitive and everyday function last, and whether additional 'booster' training sessions could provide additional benefit to aging Veterans who previously underwent treatment. This study examines the long-term durability of CCT in Veterans aged 55+ and provides an opportunity to develop and pilot test a series of CCT booster sessions that can be personalized toward individual everyday functional goals.

Key facts

Study ID

NCT05770479

Run by

VA Office of Research and Development

People needed

28

Starts

2023-07-01

Expected to finish

2028-06-30

Last updated by the study team

2026-08-06

Who can join

Age: 55 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Veterans aged 55 and older who are able to provide informed consent
• Previous completion of the "Cognitive Rehabilitation for Older Veterans with Mild Cognitive Impairment" [PI: Twamley, VA CSRD: I01CX001592] study and received the ME-CCT intervention
• Independently living
• English-speaking: this is necessary to complete cognitive and functional testing and participate in booster development and other study procedures

You may not qualify if…

• Participation in sub-study 2 of this CDA, in which study participants assist with the design of booster intervention modules
• DSM-5 criteria for current substance use disorder and has been substance abstinent for less than 30 days
• History of schizophrenia, schizoaffective disorder, or other primary psychotic disorder
• History of significant brain injury with loss of consciousness >30 minutes
• Auditory or visual impairments that would prevent ability to participate in booster sessions or ability to benefit from compensatory strategies

Where it is running

• VA San Diego Healthcare System, San Diego, CA — San Diego, California, United States

Full record on ClinicalTrials.gov

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