Internet-Behavioral Cough Suppression Therapy
Completed · Not applicable · Has a placebo group
Conditions studied: Cough, Chronic Disease
In brief
The goal of this randomized, placebo-controlled, clinical trial is to develop and test the efficacy of an Internet-based behavioral intervention for refractory chronic cough. The main questions it aims to answer are: * What are the best recruitment pathways to find people living with refractory chronic cough in Montana? * Is Internet-Behavioral Cough Suppression Therapy (iBCST) efficacious? * Do iBCST participants find it satisfactory? * Is using Hyfe research app to monitor cough frequency feasible in rural areas? Participants will complete iBCST or a placebo treatment virtually. Some participants will take part in qualitative interviews and use Hyfe research app for ambulatory cough frequency monitoring.
Key facts
- Study ID
- NCT05770401
- Run by
- University of Montana
- People needed
- 39
- Starts
- 2023-07-01
- Expected to finish
- 2024-07-01
- Last updated by the study team
- 2025-06-05
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- No barriers to using a computer or smartphone (e.g., no significant fine motor or visual problems).
- Internet and e-mail access and the ability to use it.
- Suffering from a cough lasting at least eight weeks that is:
- Largely unproductive (cough up no more than a few teaspoons worth of clear or white sputum or mucus in a 24-hour period).
- Report of cough triggered by identifiable stimuli including and not limited to any combination of the following: cold air, talking, laughing, taking a deep breath, exercise, crumbly foods, strong smells or odors, fumes from paint or cleaning sprays.
- Often preceded by the sensation of an urge-to-cough (e.g., tickle or itch) at the level of the throat.
- Self-report of receiving the following assessments for current cough symptoms with unremarkable results:
- Physical evaluation by at least one physician.
- Chest x-ray.
- Willingness to avoid other potential cough treatments during the course of the study (or alert study personnel if alternative treatment is implemented out of necessity).
You may not qualify if…
- Current smoker of any substance.
- Diagnosis of any of the following:
- Respiratory disease (e.g., chronic obstructive pulmonary disease, asthma)
- Neurogenic disease (e.g., Parkinson's disease, cerebrovascular disease)
- Head and neck cancer
- Self-report of difficulty swallowing since having chronic cough
- Use of the following medication:
- Angiotensin-converting enzyme inhibitor (ACE-I) in the past four weeks: benzapril (Lotensin), Captopril (Capoten), Enalapril/Enalaprilat (Vasotec oral and injectable), Fosinopril (Monopril), Lisinopril (Zestril and Prinivil), Moexipril (Univasc), Perindopril (Aceon), Quinapril (Accupril), Ramipril (Altace), and Trandolapril (Mavik).
- Use of a neuromodulator medication in the past 48 hours: Neurontin (Gabapentin) and amitriptyline.
- Individuals with dysphonia (abnormal voice; either self-reported or perceived by study personnel during enrollment interview) will be excluded unless they have had a normal laryngoscopy (endoscopic assessment of the larynx) by an otolaryngologist (ENT) within the past year specifically for their cough.
Where it is running
- University of Montana — Missoula, Montana, United States
Full record on ClinicalTrials.gov
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