Hydroxymethylation, Incident Type 2 Diabetes and Incident Obesity
Status unconfirmed
Conditions studied: Incident Type 2 Diabetes, Incident Obesity
In brief
The proposed discordant identical and fraternal twin study of incident type 2 diabetes and incident obesity is pivotal to public health because this study design compares diseased twins with their non-diseased co-twins for a better understanding of environment-induced hydroxymethylation independent of genetic influences as the novel biological mechanism underlying the diseases. By engaging students in the proposed co-twin control study, we will prepare our next generation of public health researchers to sustain our impact on public health across generations. The discovery of new environmentally and epigenetically therapeutic and preventive regimens will pave the way to fight against incident type 2 diabetes and incident obesity.
Key facts
- Study ID
- NCT05769439
- Run by
- Des Moines University
- People needed
- 126
- Starts
- 2021-03-01
- Expected to finish
- 2024-02-28
- Last updated by the study team
- 2023-03-15
Who can join
Age: 40 and older, up to 60. Sex: male. Healthy volunteers: not accepted.
You may qualify if…
- In the NHLBI Twin Study, middle-aged, male, veteran twins were recruited at baseline (1969-1973).
- Inclusion criteria include 1) an iT2D-discordant MZ and DZ twin pair in which one co-twin subsequently became diabetic after exam 3 through December 31, 2015 (i.e., case twin) while the other co-twin was nondiabetic on the index date (i.e., control twin); 2) an iOB-discordant MZ and DZ twin pair in which both co-twins were non-obese at exam 3 and one co-twin subsequently became obese55 after exam 3 through exam 5 (i.e., case twin) while the other co-twin was non-obese on the index date (i.e., control twin); 3) all twins must have blood DNA samples available and collected at least one year prior to the index date for each of the specific diseases (i.e., iT2D and iOB); and participant's date of birth, vital status, cause of death, death date, and date for the blood DNA collection are available.
Where it is running
- Des Moines University — Des Moines, Iowa, United States
Full record on ClinicalTrials.gov
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