Escalated Dose Proton Therapy Within the Multimodality Treatment of Glioblastoma Patients

Recruiting now · Not applicable

Conditions studied: Glioblastoma

In brief

The goal of this phase 1 dose finding study is to to assess the clinical tolerability and safety of escalated dose proton therapy in glioblastoma patients treated with multimodality treatment, according to treatment volume. The main questions it aims to answer are: * what is the maximum tolerated proton dose in glioblastoma patients? * is the maximum tolerated proton dose in glioblastoma patients dependent on treatment volume? * what is the recommended phase 2 proton dose in glioblastoma patients? Patients will be asked to undergo radiotherapy to step-wise escalated doses using proton therapy as part of their multimodality treatment. Patients will be monitored closely for treatment effects.

Key facts

Study ID

NCT05768087

Run by

University of Aarhus

People needed

36

Starts

2024-04-15

Expected to finish

2029-05-01

Last updated by the study team

2024-05-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

• All eligibility criteria are formulated as inclusion criteria.

Where it is running

• Aarhus University Hospital, Dept. of Oncology — Aarhus, Central Jutland, Denmark (enrolling)
• Danish Centre for Particle Therapy — Aarhus, Denmark (enrolling)

Full record on ClinicalTrials.gov

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