Early Neurophysiological Markers of Language Impairments

Recruiting now

Conditions studied: Development, Infant, Development, Language, Developmental Language Disorder, Learning Disabilities

In brief

The present project aims at identifying very early electrophysiological risk markers for language impairments. The long-term goals of the study include the characterization of learning developmental trajectories in children at high risk for language impairments. In this project, all the infants of the Medea BabyLab cohort are followed-up until school age. Since these infants have complete information on early electrophysiological markers, the final goal of the project is the characterization of their learning developmental trajectories and the construction of a multi-factor prognostic model that includes the neurophysiological processes underlying basic-level skills as potential biomarkers for predicting later reading and spelling skills.

Key facts

Study ID

NCT05767242

Run by

IRCCS Eugenio Medea

People needed

100

Starts

2022-02-21

Expected to finish

2026-12-31

Last updated by the study team

2025-02-05

Who can join

Age: 1 and older, up to 8. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy infants aged <24 months
• Infants with and without familial risk for language impairments (infants are assigned to the group with familial risk if at least one first-degree relative had a certified (clinical) diagnosis of language impairment or learning disability
• Both parents are native-Italian speakers

You may not qualify if…

• Gestational age < 37 weeks and/or birth weight < 2500 grams
• APGAR scores at birth at 1' and 5' < 7
• Bayley Cognitive Score < 7
• Presence of certified diagnosis of intellectual deficiency, attention-deficit disorder, sensorial and neurological disorders, or autism within first-degree relative

Where it is running

• Associazione La Nostra Famiglia - IRCCS Eugenio Medea — Bosisio Parini, LC, Italy (enrolling)

Full record on ClinicalTrials.gov

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