Diagnosing Variable Primary Aldosteronism.

Recruiting now

Conditions studied: Primary Aldosteronism, High Blood Pressure

In brief

The goal of this observational study is to see if there is a cyclical or exaggerated diurnal variation in aldosterone production in people with Primary Aldosteronism.

Key facts

Study ID

NCT05765786

Run by

Queen Mary University of London

People needed

100

Starts

2023-02-24

Expected to finish

2027-07-24

Last updated by the study team

2026-06-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• People with clinically suspected PA but have not met criteria for diagnosis. Suspicion based on low-renin (renin activity <0.5 nmol/h/L or renin mass <5 ng/L), plasma sodium > 140mmol/L or plasma potassium < 4mmol/L.
• Patients who have been diagnosed with PA and had previous aldosterone samples <277 pmol/L, a level which would normally not qualify for confirmatory testing.
• Patients with aldosterone results done at different times that indicate variability in production.
• Willing to consent and participate in the study.

You may not qualify if…

• Inability to withdraw β-adrenoceptor antagonist therapy for 2 weeks.
• People on end of life treatment.

Where it is running

• Queen Mary University of London — London, United Kingdom (enrolling)

Full record on ClinicalTrials.gov

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