SPEECH as Biomarker for Emotion, Movement and cOgnition in Parkinson's Disease
Recruiting now · Not applicable
Conditions studied: Parkinson Disease
In brief
With this study, the investigators want to investigate whether computerized speech analysis can be used to reliably and objectively detect motor, emotional, and cognitive fluctuations in Parkinson's disease patients.
Key facts
- Study ID
- NCT05765110
- Run by
- Insel Gruppe AG, University Hospital Bern
- People needed
- 80
- Starts
- 2023-01-03
- Expected to finish
- 2026-12-31
- Last updated by the study team
- 2026-05-22
Who can join
Age: 30 and older, up to 75. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Written informed consent
- Idiopathic PD according to the Movement Disorders Society Criteria;
- Age of participants > 30 and ≤ 75 years;
- Treatment with or without bilateral deep brain stimulation in the subthalamic nucleus;
- Fluent in German or French
You may not qualify if…
- Dysarthria caused in addition by a condition other than PD (e.g. stroke, myasthenia);
- Clinical diagnosis of aphasia;
- Brain disease other than Parkinson's disease (e.g. atypical Parkinsonism, Alzheimer's disease, vascular dementia, multiple sclerosis, stroke, traumatic brain injury, epilepsy, etc.).
- Cognitive impairment (Montreal Cognitive Assessment (MoCa) < 24/30 points);
- Depression with acute suicidal ideation
- Healthy Controls
- Inclusion Criteria:
- Written informed consent
- Adults from 50-70 years old;
- Fluent in German or French
- Exclusion Criteria:
- Diagnosis of Parkinson's disease;
- Cognitive impairment (Montreal Cognitive Assessment (MoCa) < 24/30 points);
- Suffering from brain disease (e.g. atypical Parkinsonism, Alzheimer's disease, vascular dementia, multiple sclerosis, stroke, traumatic brain injury, epilepsy, etc.);
- Clinical diagnosis of aphasia, dysarthria, and stuttering;
- Suffering from or diagnosed with psychiatric illnesses according to DSM-V criteria
Where it is running
- University Hospital Inselspital, Berne — Bern, Switzerland (enrolling)
- Czech Technical University Prague — Prague, Czechia
Full record on ClinicalTrials.gov
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