A Study of Tumor-Treating Fields (TTFields) in People With Lung Adenocarcinoma

Running, not enrolling · Phase 1

Conditions studied: Adenocarcinoma of Lung

In brief

The researchers are doing this study to find out if treatment with TTFields using the NovoTTF-200T System is safe and practical (feasible) before surgical removal (resection) of lung adenocarcinoma (ADC). The researchers will also look at how the treatment may help the body's immune system to fight cancer.

Key facts

Study ID

NCT05764954

Run by

Memorial Sloan Kettering Cancer Center

People needed

12

Starts

2023-08-04

Expected to finish

2027-08-01

Last updated by the study team

2026-05-28

Who can join

Age: 22 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• The participant (or legally acceptable representative [LAR], if applicable) provides written informed consent for the study.
• The participant is ≥22 years of age on the day of signing informed consent.
• The participant has clinical stage 1A2, 1A3 or IB biopsy-proven lung ADC and is eligible for anatomical resection.
• The participant has a lung nodule >1 cm and suspected lung ADC with a plan to undergo biopsy.
• The participant with multiple nodules has one nodule that meets the criteria.
• The participant has no history of prior malignancy in the chest or has undergone potentially curative therapy with no evidence of that disease recurrence for 5 years since initiation of that therapy.

You may not qualify if…

• Patients receiving therapy for concurrent active malignancy
• Patients with a history of cardiac arrhythmias and/or pacemaker use
• Patients with lung nodules <1cm
• Patients with lung nodules that are pure ground glass opacities (GGOs) of any size
• Patients with lung nodules that are <50% solid of any size

Where it is running

• Memorial Sloan Kettering Basking Ridge (Consent Only) — Basking Ridge, New Jersey, United States
• Memorial Sloan Kettering Monmouth (Consent Only) — Middletown, New Jersey, United States
• Memorial Sloan Kettering Bergen (Consent Only) — Montvale, New Jersey, United States
• Memorial Sloan Kettering Suffolk - Commack (Consent Only) — Commack, New York, United States
• Memorial Sloan Kettering Westchester (Consent Only) — Harrison, New York, United States
• Memorial Sloan Kettering Cancer Center (All Protocol Activities) — New York, New York, United States
• Memorial Sloan Kettering Nassau (Consent Only) — Uniondale, New York, United States

Full record on ClinicalTrials.gov

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