The Potential of Oxytocin to Reduce Opioid Abuse Liability and Pain Among Older Adults

Recruiting now · Early Phase 1 · Has a placebo group

Conditions studied: Pain

In brief

Some research suggests that administration of oxytocin with oxycodone may reduce its abuse liability and improve its ability to reduce pain. In a 6-session laboratory study, we will be evaluating the effects of oxycodone and oxytocin (combined and separately, across sessions) on experimentally-induced pain, subjective effects, and decision-making.

Key facts

Study ID

NCT05761860

Run by

University of Florida

People needed

45

Starts

2023-09-12

Expected to finish

2027-07-01

Last updated by the study team

2026-05-01

Who can join

Age: 45 and older, up to 85. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Individuals fluent in English will participate.
• Must report some experience with opioids (e.g., oxycodone, defined as use at least once in the subject's lifetime).
• Be within 20% of their ideal body weight.
• Are not currently experiencing chronic pain (pain on most days during the past 3 months)
• Have a systolic blood pressure of <=140 and diastolic blood pressure of <= 90, and a heart rate <= 90 beats per minute.
• Participants must also have a normal electrocardiogram (EKG) reading and bloodwork indicating no major health contraindications.

You may not qualify if…

• Significant current physical disease or major (uncontrolled) psychiatric disorder.
• No self-reported current interest in drug abuse treatment.
• Women who are pregnant or nursing.
• Any severe comorbid illicit substance use disorders or current clinically significant withdrawal for any abused drug excluding nicotine and caffeine.

Where it is running

• University of Florida — Gainesville, Florida, United States (enrolling)

Full record on ClinicalTrials.gov

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