Solid Tumors in RASopathies

Recruiting now · Not applicable

Conditions studied: RASopathy, Costello Syndrome, Cardio-Facio-Cutaneous Syndrome, Noonan Syndrome

In brief

RASopathies are a group of syndromes, caused by variants of genes involved in the regulation of the Ras/MAP/ERK pathway. This intracellular transduction pathway profoundly affects embryogenic development, organogenesis, synaptic plasticity and neuronal growth. RASopathies are characterized by multi-organ involvement, growth delay, premature aging and haemato-oncological manifestations. Based on evidences provided by literature, cancer screening protocols are applied in some individuals affected by RASopathies, even though detailed information about prevalence and molecular pathogenesis of such tumors is still not clearly elucidate.

Key facts

Study ID

NCT05761314

Run by

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

People needed

100

Starts

2021-10-12

Expected to finish

2026-10-12

Last updated by the study team

2024-04-04

Who can join

Age: any. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Clinical and molecularly confirmed diagnosis of a RASopathy

You may not qualify if…

• Clinical diagnosis of RASopathy without molecular characterization

Where it is running

• Department of Woman and Child Health and Public Health, Fondazione Policlinico A. Gemelli, IRCCS — Roma, Italy (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.