Oropharyngeal Candidiasis (OPC) and S-ECC

Recruiting now

Conditions studied: Candida Infection, Oral Thrush, Early Childhood Caries

In brief

The overall objective of this study is to investigate the association of early Candida infection (known as oral thrush or oropharyngeal candidiasis, OPC) in children during the first year of life with the onset and severity of severe early childhood caries (S-ECC).

Key facts

Study ID

NCT05761197

Run by

Temple University

People needed

70

Starts

2024-09-01

Expected to finish

2028-08-31

Last updated by the study team

2026-06-22

Who can join

Age: 1 and older, up to 1. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Male or female individuals at the age of 9-15-month-old
• Must have at least one fully erupted tooth at baseline visit
• Parent/guardian willing and able to provide informed consent
• With or without a history of OPC (the study team will enroll 35 participants with and 35 participants without a history of OPC)

You may not qualify if…

• Presence of a systemic medical condition (e.g. Down syndrome etc.)
• Presence of an orofacial deformity
• Presence of dental caries
• Use of systemic antimicrobial therapy within 30 days of the baseline visit
• Presence of any condition which, in the opinion of the investigator, makes participation in the project not in the individual's best interest.

Where it is running

• Temple University — Philadelphia, Pennsylvania, United States (enrolling)

Full record on ClinicalTrials.gov

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