OCT Vibrography for Biomechanical Properties of Tissues

Recruiting now · Not applicable

Conditions studied: Cornea, Skin Diseases, Gingival Diseases

In brief

The overall goal of this study is to develop OCT Vibrography (aka OCT elastography) as a novel tool for measuring biomechanical properties of human tissues in vivo.

Key facts

Study ID

NCT05759780

Run by

Massachusetts General Hospital

People needed

90

Starts

2023-08-19

Expected to finish

2026-08-28

Last updated by the study team

2025-10-23

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Subjects with healthy eyes (age 18 - 75, N = 50)

You may not qualify if…

• Subjects with history of eye diseases, and previous eye surgeries.
• Subjects with diabetes, glaucoma family history
• Subjects allergic to anesthetic eyedrop, especially proparacaine
• Subjects with severe allergy
• Subjects who have difficulty biting
• Subjects who have recurrent corneal erosion
• Group 2:
• Inclusion criteria:
• Subjects with healthy skin (age 18 - 75, N = 10)
• Exclusion criteria:
• Subjects with open cuts/sores on the skin, skin infection, or any contagious skin condition
• Group 3:
• Inclusion criteria:
• Subjects with healthy gingiva (age 18 - 75, N = 10)
• Exclusion criteria:
• Subjects with open cuts/sores on the gingiva, gingiva infection, or any contagious gingiva condition
• Group 4:
• Inclusion criteria:
• Mild or moderate keratoconus subjects (age 18 - 40, N = 20)
• Exclusion criteria:
• Subjects with K-max above 60 diopters (Pentacam imaging) are excluded

Where it is running

• Massachusetts General Hospital — Boston, Massachusetts, United States (enrolling)

Full record on ClinicalTrials.gov

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