PROton Therapy for Post Surgical Treatment of GYNecologic Cancer

Recruiting now · Phase 2

Conditions studied: Cervical Cancer, Uterine Cancer, Endometrial Cancer

In brief

This is a single institution, multi-center, Phase II, single-arm study, using Whole Pelvis (WP) Pencil Beam Scanning Proton Radiation (PBS PRT) in the post-surgical, adjuvant setting for definitive treatment of gynecologic cancers. The purpose of this study is to estimate rate of acute clinician-reported gastrointestinal (GI) toxicity using WP PBS PRT in the definitive treatment of gynecologic cancers in the post-surgical, adjuvant setting.

Key facts

Study ID

NCT05758688

Run by

Abramson Cancer Center at Penn Medicine

People needed

25

Starts

2023-11-06

Expected to finish

2026-12-01

Last updated by the study team

2026-06-10

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Histologically confirmed cervical or endometrial cancer
• Indication for adjuvant whole pelvic radiation therapy, with or without systemic therapy
• Age of 18 years or older
• Written informed consent
• ECOG of 0-2 within 3 months of enrolling

You may not qualify if…

• Prior course of pelvic radiation
• Metastatic disease outside of the pelvis
• Active inflammatory bowel disease
• Incapacity to provide informed consent

Where it is running

• Virtua Health — Voorhees Township, New Jersey, United States (enrolling)
• Lancaster General Health - Ann B. Barshinger Cancer Institute — Lancaster, Pennsylvania, United States (enrolling)
• University of Pennsylvania — Philadelphia, Pennsylvania, United States (enrolling)

Full record on ClinicalTrials.gov

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