An Open-label Study of Povetacicept in Participants With Autoimmune Cytopenias

Running, not enrolling · Phase 1/Phase 2

Conditions studied: Immune Thrombocytopenia, Idiopathic Thrombocytopenic Purpura, Warm Autoimmune Hemolytic Anemia, Cold Agglutinin Disease

In brief

The goal of this clinical study is to evaluate povetacicept in adults with autoimmune cytopenias of immune thrombocytopenia, autoimmune hemolytic anemia, and cold agglutinin disease to determine if povetacicept is safe and potentially beneficial in treating these diseases. During the study treatment period participants will receive povetacicept approximately every 4 weeks for 6 months, with the possibility of participating in a 6-month study treatment extension period.

Key facts

Study ID

NCT05757570

Run by

Alpine Immune Sciences, Inc.

People needed

30

Starts

2023-07-03

Expected to finish

2026-07-01

Last updated by the study team

2026-07-28

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Investigational Site (418) — Istanbul, Turkey (Türkiye)
• Investigational Site (442) — Leeds, United Kingdom
• Investigational Site (230) — Los Angeles, California, United States
• Investigational Site (401) — Washington D.C., District of Columbia, United States
• Investigational Site (419) — Cooper City, Florida, United States
• Investigational Site (425) — Miami, Florida, United States
• Investigational Site (219) — Iowa City, Iowa, United States
• Investigational Site (435) — Columbia, Maryland, United States
• Investigational site (405) — Lake Success, New York, United States
• Investigational Site (423) — New Hyde Park, New York, United States
• Investigational Site (421) — New York, New York, United States
• Investigational Site (404) — New York, New York, United States
• Investigational Site (420) — Shirley, New York, United States
• Investigational Site (422) — The Bronx, New York, United States
• Investigational Site (414) — Charlotte, North Carolina, United States
• Investigational Site (402) — Greenville, North Carolina, United States
• Investigational Site (411) — Seattle, Washington, United States
• Investigational Site (410) — Box Hill, Australia
• Investigational Site (519) — Concord, Australia
• Investigational Site (517) — Douglas, Australia
• Investigational Site (413) — Liverpool, Australia
• Investigational Site (407) — West Perth, Australia
• Investigational Site (409) — Westmead, Australia
• Investigational Site (434) — Vienna, Austria
• Investigational Site (406) — Greenfield Park, Canada

Full record on ClinicalTrials.gov

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