The Brain Metabolism of Unpredictable Signals
Completed · Not applicable
Conditions studied: Healthy
In brief
The investigators will be studying brain glucose and oxygen metabolism using hybrid PET/fMRI imaging to better understand how decoupling between brain glucose and oxygen metabolism relates to the processing of unpredictable sensory signals.
Key facts
- Study ID
- NCT05756335
- Run by
- Massachusetts General Hospital
- People needed
- 24
- Starts
- 2024-04-05
- Expected to finish
- 2026-02-12
- Last updated by the study team
- 2026-07-02
Who can join
Age: 21 and older, up to 35. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Adults aged 21-35.
- No contraindications to MRI or PET scanning.
- Right-handed.
- Fluent to speak, read, and understand English.
You may not qualify if…
- Adults unable to consent
- Contraindications to fMRI scanning and PET scanning (including the presence of a cardiac pacemaker or pacemaker wires, metallic particles in the body, vascular clips in the head or previous neurosurgery, prosthetic heart valves, claustrophobia)
- Inability to lie motionless in the scanner
- Pregnancy, seeking or suspecting pregnancy, or breastfeeding
- History of major head trauma
- Intracranial lesion
- Cardiovascular disorders, including heart disorders or high blood pressure [>155/95]
- Breathing problems such as severe asthma, emphysema, or pulmonary disease
- Bleeding disorder, or use of anticoagulants
- Bladder obstruction, urinary problems, or history of impaired elimination
- Known kidney or liver problems
- Past severe COVID-19 infection
- Intestinal blockage
- Raynaud syndrome
- Anemia
- Peripheral nerve injury
- Diabetes
- Glaucoma
- Current or recent use of medications (neurological or psychiatric) affecting brain function
- Current or past history of major medical, neurological, or psychiatric condition
- Current or past history of chronic pain (assessed at the discretion of PI)
- Current smoker
- Body mass index above 35
- Research-related radiation exposure exceeds current Radiology Department guidelines
- Lack of current health insurance coverage
Where it is running
- Athinoula A. Martinos Center for Biomedical Imaging — Charlestown, Massachusetts, United States
Full record on ClinicalTrials.gov
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