Blood Pressure Variability and Ischemic Stroke Outcome

Recruiting now

Conditions studied: Acute Ischemic Stroke, Blood Pressure Variability

In brief

The goal of this observational study is to evaluate the role of blood pressure (BPV) variability in patients suffering from acute ischemic stroke. The main questions it aims to answer are: 1. To determine the association of BPV with functional/cognitive outcome after ischemic stroke. 2. To determine a pathophysiologic mechanism of BPV's deleterious effect on functional outcome. 3. To evaluate potential treatment targets to pharmacologically reduce BPV after ischemic stroke.

Key facts

Study ID: NCT05756257
Run by: Yale University
People needed: 150
Starts: 2024-07-15
Expected to finish: 2026-07-30
Last updated by the study team: 2026-05-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Ischemic stroke according to the American Heart Association (AHA) definition and either:
CT or MRI showing ischemic stroke in the anterior circulation (frontal, parietal or superior temporal lobes), or
Occlusion of the internal carotid, middle cerebral or anterior cerebral arteries on computed tomography angiography (CTA) or magnetic resonance angiography (MRA)
Onset of ischemic stroke within 48 hours and able to get baseline pMRI within 72 hours of arrival
NIH Stroke Scale ≥ 4 at time of enrollment

You may not qualify if…

Pre-morbid mRS ≥3
Predicted hospital system admission <72 hours
Pacemaker or other MRI contraindications per American College of Radiology guidelines

Where it is running

Yale-New Haven Hospital — New Haven, Connecticut, United States (enrolling)
University of Chicago Medical Center — Chicago, Illinois, United States (enrolling)
Massachusetts General Hospital — Boston, Massachusetts, United States (enrolling)

Full record on ClinicalTrials.gov

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