PRospective Evaluation of Peripartum Anticoagulation ManaGement for ThrOmboembolism

Recruiting now

Conditions studied: Pregnancy Related, Venous Thromboembolism

In brief

The PREP and GO study is an international multicentre prospective cohort evaluating anticoagulation management strategies around labor and delivery and the postpartum period.

Key facts

Study ID

NCT05756244

Run by

University of Calgary

People needed

825

Starts

2023-04-04

Expected to finish

2029-12-31

Last updated by the study team

2025-11-28

Who can join

Age: 18 and older, up to 60. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• 18 years of age or older
• Requires anticoagulation during the antepartum period of pregnancy for a VTE indication, including at least one of:
• Objectively confirmed VTE (DVT, superficial vein thrombosis [SVT], PE or unusual site thrombosis) diagnosed during the current pregnancy;
• Objectively confirmed VTE diagnosed in a prior pregnancy;
• Objectively confirmed VTE diagnosed when not pregnant;
• Inherited or acquired thrombophilia requiring anticoagulation.
• Receiving any dose or type of LMWH during the antepartum period

You may not qualify if…

• Anticoagulation for a non-VTE indication, including prosthetic heart valves, atrial fibrillation, prevention of placenta-mediated pregnancy complications, or prevention of recurrent pregnancy loss (participants can be included with a diagnosis of antiphospholipid syndrome (APS) with or without thrombotic events)
• Unable to provide or declined consent.
• Home or birthing centre planned delivery.

Where it is running

• Duke University Hospital — Durham, North Carolina, United States (enrolling)
• Foothills Medical Centre — Calgary, Alberta, Canada (enrolling)
• Royal Alexandra Hospital — Edmonton, Alberta, Canada (enrolling)
• BC Women's Hospital and Health Centre — Vancouver, British Columbia, Canada (enrolling)
• St. Boniface Hospital — Winnipeg, Manitoba, Canada (enrolling)
• McMaster University Medical Centre — Hamilton, Ontario, Canada (enrolling)
• The Ottawa Hospital - General Campus — Ottawa, Ontario, Canada (enrolling)
• Montfort Hospital — Ottawa, Ontario, Canada (enrolling)
• Mount Sinai Hospital — Toronto, Ontario, Canada (enrolling)
• CHU Sainte-Justine — Montreal, Quebec, Canada (enrolling)
• The Sir Mortimer B. Davis Jewish General Hospital — Montreal, Quebec, Canada (enrolling)
• Aarhus University Hospital — Aarhus, Denmark (enrolling)
• Le Centre Hospitalier Universitaire of Saint-Etienne — Saint-Etienne, France (enrolling)
• Hopitaux universitaires de Geneve — Geneva, Switzerland (enrolling)

Full record on ClinicalTrials.gov

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