Determining the Association of Microvascular Disease as Assessed by PET and Graft Injury by Donor Derived Cell Free DNA

Withdrawn before enrolling

Conditions studied: Cardiac Allograft Vasculopathy, Endothelial Dysfunction, Microvascular Coronary Artery Disease

In brief

The goal of this research study is to understand if a blood test in people who have had heart transplants can detect and predict the following: * Blockages in the small blood vessels of the heart. * Whether small blockages can turn into more severe blockages in the future. Participants will undergo blood draws once every 3 months in the first year of the study (4 blood draws total, taking 15 minutes each) and their medical records will be reviewed for 3 years after the date they are enrolled in the study.

Key facts

Study ID

NCT05756088

Run by

Yale University

People needed

0

Starts

2025-12-01

Expected to finish

2030-06-01

Last updated by the study team

2025-11-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

• Evidence of moderate to large area of ischemia on the PET.
• Multiorgan transplantation.
• Life expectancy <1 year due to non-cardiac conditions.
• Less than 3 years from transplantation.
• Patient appears unlikely or unable to participate in the required study procedures, as assessed by the study PI, study coordinator, or designee (ex: clinically-significant psychiatric, addictive, or neurological disease).

Where it is running

• Yale New Haven Health — New Haven, Connecticut, United States

Full record on ClinicalTrials.gov

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