Procalcitonin Protocol Use to Guide Antibiotic Therapy Duration in the Intensive Care Unit

Status unconfirmed

Conditions studied: Comparing Antibiotic Duration of Therapy

In brief

To compare and contrast antibiotic use and its effects on patient outcomes before and after the implementation of a PCT protocol in the ICU at Methodist Richardson Medical Center (MRMC).

Key facts

Study ID

NCT05756049

Run by

Methodist Health System

People needed

208

Starts

2022-11-29

Expected to finish

2024-11-29

Last updated by the study team

2024-03-27

Who can join

Age: 18 and older, up to 100. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• ● Patients aged 18 years or older
• Patients being monitored on the PCT protocol
• ICU location status for at least part of the admission
• Received antibiotics in the ICU for a diagnosis of:
• Community-acquired pneumonia
• Hospital-acquired pneumonia
• Ventilator-associated pneumonia
• Sepsis and/or septic shock
• Uncomplicated bacteremia with known source
• Chronic obstructive pulmonary disorder exacerbation
• Asthma exacerbation

You may not qualify if…

• Received antibiotics in the ICU for a diagnosis of:
• Uncomplicated skin and soft tissue infections
• Abscess
• Empyema
• Bacterial infections that require prolonged antibiotic therapy (e.g., osteomyelitis, endocarditis, tuberculosis, etc.)
• Intra-abdominal infection
• Urinary tract infection
• Bacterial meningitis
• Estimated Glomerular Filtration Rate <15 mL/min
• Requiring renal replacement therapy
• Status post cardiac arrest/target temperature management

Where it is running

• Methodist Richardson Medical Center — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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