Fruit-based Chewing Gums for Improving Oral Health

Completed · Not applicable

Conditions studied: Oral Health

In brief

This study aims to conduct a randomized cross-over study investigating the release of cranberry polyphenols from chewing gum formulated with polyphenol-lecithin precipitate (PLP). 10 participants will be on study for up to 2 weeks and will each complete 2-30 minute study intervention visits.

Key facts

Study ID

NCT05755152

Run by

University of Wisconsin, Madison

People needed

10

Starts

2023-10-10

Expected to finish

2023-10-26

Last updated by the study team

2023-11-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• healthy adults 18 years and older
• willing to avoid foods, beverages, tobacco products, and additional gum in the wash-in and wash-out periods
• willing to chew the intervention gum during the sampling periods
• willing to provide saliva and gum samples during the sampling periods
• willing to fill out post-visit surveys after their visits

You may not qualify if…

• Participants who do not consider themselves healthy
• have less than 20 natural teeth and 8 natural posterior teeth (excluding third molars)
• have a salivary rate ≥ 0.3 mL/min as determined from an unstimulated salivary flow trial
• taking medications that contraindicates grapefruit juice consumption
• allergic to any intervention foods or ingredients (e.g. sunflower, soy, food colorants, berry ingredients, or any other component of the study gum)
• diagnosed with phenylketonuria (PKU), gross untreated caries, advanced gingivitis and periodontitis, and temporomandibular joint disorder
• participants who are pregnant or lactating

Where it is running

• Babcock Hall — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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