Burst-Type Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson's Disease

Stopped early · Not applicable

Conditions studied: Parkinson Disease, Deep Brain Stimulation

In brief

This is a study to evaluate Deep brain stimulation (DBS) burst-type electrical stimulation programming verses standard DBS programming. Burst-type DBS is defined as a novel stimulation protocol in which intermittent bursts of traditional high-frequency rectangular wave stimulation are delivered. Burst type DBS may improve the efficacy and durability of DBS pulse generator.

Key facts

Study ID

NCT05753449

Run by

Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)

People needed

2

Starts

2022-08-24

Expected to finish

2024-02-21

Last updated by the study team

2025-05-28

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Bilateral DBS-STN (subthalamic nucleus) target for idiopathic Parkinson's disease implanted minimum 6 months prior to the day of study enrollment
• Stable DBS programming settings and Parkinson's disease medications defined as no changes to either within past 2 weeks
• Comfortable using DBS controller to turn off device prior to study visits
• Able to provide informed consent and complete follow-up visits

You may not qualify if…

• DBS technology other than Boston scientific Genus/Gevia
• Unable to complete follow-up visits
• DBS brain targets other than STN (subthalamic nucleus)
• Signs of progressive cognitive decline

Where it is running

• AHN Allegheny General Hospital — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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