Analgesia-First Sedation in Trauma Patients

Recruiting now · Not applicable

Conditions studied: Mechanical Ventilation, Respiratory Failure

In brief

The study's aim is to ascertain the best approach for providing sedation and pain management for patients who have sustained trauma and are requiring respiratory support from a mechanical ventilator. The common approach to patients who need mechanical ventilation is to provide continuous drips of sedatives and pain medicine and awaken the patient once a day to check the brain functions. Another approach is to provide pain medicine and reserve sedatives for only a short duration when needed. The difference between approaches has not been studied in Trauma patients.

Key facts

Study ID

NCT05751863

Run by

MemorialCare Health System

People needed

170

Starts

2023-04-01

Expected to finish

2026-09-01

Last updated by the study team

2025-07-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• ≥ 18 years of age
• Mechanically ventilated with an expected duration of MV ≥ 48h
• Initiated continuous sedative/analgesic infusions by the ICU team
• Patient is a candidate for MV weaning

You may not qualify if…

• Admission after resuscitation from cardiac arrest
• Significant neurological deficit due to a chronic disorder
• History of alcohol dependence and/or other illicit drug abuse
• Prior administration of continuous sedative/analgesic from a transferring institution
• Patient receiving neuromuscular blocking agents
• Allergy to midazolam, lorazepam, and/or propofol

Where it is running

• Long Beach Memorial Medical Center — Long Beach, California, United States (enrolling)

Full record on ClinicalTrials.gov

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