Cryoprobe Versus Forceps for Transbronchial Biopsy

Completed · Not applicable

Conditions studied: Lung Diseases

In brief

The purpose of this study is to compare the effectiveness of transbronchial biopsy done by a 1.1mm cryoprobe versus the standard 2.0mm forceps.

Key facts

Study ID

NCT05751278

Run by

Johns Hopkins University

People needed

500

Starts

2023-02-27

Expected to finish

2026-03-02

Last updated by the study team

2026-04-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or Female, ≥ 18-years-old
• Scheduled to undergo bronchoscopy with transbronchial biopsy per standard of care

You may not qualify if…

• Pregnant or nursing woman or woman of child-bearing potential who refuse to take a pregnancy test prior to enrollment
• Severe pulmonary hypertension (RVSP > 60 mmHg)
• Stroke within the last 6 months or myocardial infarction within the last 3 months
• Presence of bleeding disorder
• Platelet count < 50,000 per mL at time of enrollment
• Use of systemic anticoagulation or antiplatelet therapy without the ability to hold therapy for the recommended time prior to invasive procedure (aspirin monotherapy is acceptable)
• Do Not Resuscitate (DNR) status
• Do Not Intubate (DNI) status

Where it is running

• Northwestern Medicine — Chicago, Illinois, United States
• University of Maryland, Baltimore (UMB) — Baltimore, Maryland, United States
• Johns Hopkins Hospital — Baltimore, Maryland, United States
• Washington University in Saint Louis (Wash-U) — St Louis, Missouri, United States
• NYU Langone Health — New York, New York, United States
• Duke University Medical Center — Durham, North Carolina, United States
• University of Pennsylvania — Philadelphia, Pennsylvania, United States
• The Medical University of South Carolina — Charleston, South Carolina, United States
• Vanderbilt University Medical Center (VUMC) — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

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