ENCALM: A Study of ENX-102 as a Monotherapy Treatment in Patients With Generalized Anxiety Disorder

Completed · Phase 2 · Has a placebo group

Conditions studied: Generalized Anxiety Disorder

In brief

The ENCALM trial is designed to evaluate the efficacy and safety of ENX-102 in patients diagnosed with generalized anxiety disorder (GAD)

Key facts

Study ID

NCT05749055

Run by

Engrail Therapeutics INC

People needed

252

Starts

2023-07-03

Expected to finish

2025-09-18

Last updated by the study team

2025-09-25

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

Where it is running

• IMA Clinical Research Phoenix — Phoenix, Arizona, United States
• Collaborative Neuroscience Research, LLC (CNS) — Garden Grove, California, United States
• Sun Valley Research Center — Imperial, California, United States
• Alliance Research — Long Beach, California, United States
• NRC Research Institute — Los Angeles, California, United States
• Excell Research, Inc. — Oceanside, California, United States
• Anderson Clinical Research — Redlands, California, United States
• California Neuroscience Research, LLC — Sherman Oaks, California, United States
• Pacific Clinical Research Management Group — Upland, California, United States
• Sunwise Clinical Research — Walnut Creek, California, United States
• Mountain View Clinical Research — Denver, Colorado, United States
• Vertex Clinical Research — Clermont, Florida, United States
• Clinical Neuroscience Solutions, Inc. — Jacksonville, Florida, United States
• Accel Research Sites Network - Lakeland CRU — Lakeland, Florida, United States
• Accel Research Sites Network - Maitland CRU — Maitland, Florida, United States
• Clinical Neuroscience Solutions, Inc. — Orlando, Florida, United States
• CenExel iResearch, LLC — Savannah, Georgia, United States
• Collective Medical Research — Overland Park, Kansas, United States
• Boston Clinical Trials — Boston, Massachusetts, United States
• Precise Research Centres — Flowood, Mississippi, United States
• IMA Clinical Research — Las Vegas, Nevada, United States
• SPRI Clinical Trials, LLC — Brooklyn, New York, United States
• Neurobehavioral Research — Cedarhurst, New York, United States
• Richmond Behavioral Associates — Staten Island, New York, United States
• Clinical Neuroscience Solutions, Inc. — Memphis, Tennessee, United States

Full record on ClinicalTrials.gov

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