Lung Function Outcomes Following Removal of Airway Mucus Plugs in Patients With Asthma (FOCUS)

Withdrawn before enrolling · Not applicable

Conditions studied: Asthma

In brief

This is a single-center study that will evaluate the safety and tolerability of removal of mucus plugs by bronchoscopy in patients with asthma. This protocol will also plan for the analysis of the features of the mucus plugs removed.

Key facts

Study ID

NCT05748912

Run by

University of California, San Francisco

People needed

0

Starts

2022-01-26

Expected to finish

2025-03-25

Last updated by the study team

2026-01-13

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Males or females between the ages 18 to 70 at the time of visit 1.
• Clinical history of asthma per patient report or medical record.
• Pre-bronchodilator FEV1 < 80% predicted and ≥ 35% predicted
• CT mucus plug score > 5.
• Written informed consent obtained from subject and ability for subject to comply with the requirements of the study.

You may not qualify if…

• Smoking of tobacco or other recreational inhalants in the last month and/or >10 pack-year smoking history.
• History of other pulmonary disorders including cystic fibrosis and COPD (Chronic Obstructive Pulmonary Disease).
• History of unstable cardiovascular disease.
• BMI > 45
• Current use of anticoagulant medications.
• Upper Respiratory Infection (URI) within the previous 6 weeks
• Currently pregnant and/or unwillingness to practice medically acceptable birth control or complete abstinence during the study
• History of COVID-19 (coronavirus disease) in the past 6 months.
• Protocol B:
• Inclusion Criteria:
• Males or females between the ages 18 to 80 at the time of visit 1.
• Undergoing clinically indicated bronchoscopy for removal of mucus plugs.
• Clinical history of airway disease (including asthma, COPD and bronchiectasis) per patient report or medical record.
• Written informed consent obtained from subject.
• Exclusion Criteria:
• Upper Respiratory Infection (URI) in the past 30 days.
• History of COVID-19 in the past 30 days.
• Currently pregnant during the study.

Where it is running

• UCSF Airway Clinical Research Center — San Francisco, California, United States

Full record on ClinicalTrials.gov

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