Promising ROd-cone DYstrophy Gene therapY

Running, not enrolling · Phase 1/Phase 2

Conditions studied: Retinitis Pigmentosa

In brief

This is a two-step, multicenter, Phase I/II study including an open-label dose-escalation phase (Step 1) and a three-arm, controlled, double-masked, randomized extension phase (Step 2), in subjects with advanced RCD due to a mutation in the RHO, PDE6A, or PDE6B gene (Step 1), or in any RCD-causative gene (Step 2).

Key facts

Study ID: NCT05748873
Run by: SparingVision
People needed: 33
Starts: 2023-04-12
Expected to finish: 2031-02-01
Last updated by the study team: 2026-05-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Subjects will be eligible to participate in this study only if all the following criteria apply:
Able to give signed informed consent and comply with the requirements and restrictions listed in the informed consent form (ICF) and in the protocol.
Age ≥18 years at the time of ICF signature.
Subjects of either gender previously diagnosed with advanced RCD due to: in Step 1, biallelic mutations in the rod cGMP phosphodiesterase 6 beta (PDE6B) or rod cGMP phosphodiesterase alpha (PDE6A) genes, or a monoallelic dominant mutation in the rhodopsin (RHO) gene; in Step 2, mutations in any RCD-causative gene (such as variants classified as 'pathogenic/likely pathogenic'). The genotyping results must be documented before the initiation of the Screening Visit. Subjects should be retested by the investigator if their genotyping tests were not performed within the 7 previous years, or if they were not performed by an accredited laboratory.
Advanced stage is defined as a stage of the natural history of the disease where both distance visual acuity and visual field are affected in both eyes. The Study Eye should meet the definition of one of the following substages within the advanced stage (monocular measurements, horizontal axis of isopter III4e for the visual field):
Severe stage is defined by both a BCVA below or equal to 20/200 and above or equal to 20/800, and a visual field below or equal to 20 degrees (subjects of Cohorts 1 to 3)
Intermediate stage is defined by both a BCVA below or equal to 20/40 and above or equal 20/200, and a visual field below or equal to 30 degrees (subjects of Cohorts 4 to 6)
For subjects with severe advanced RCD enrolled in Step 1 only, the difference in visual acuity between the two eyes of a given subject should be equal to or below 0.3 logarithm of the minimal angle (LogMAR) (≤3 ETDRS lines), with a tolerance margin of 3 ETDRS letters.
Clinical diagnosis of RCD based on past medical and family history, mid-peripheral visual field dysfunction, photopsia, night blindness (nyctalopia), and fundoscopic appearance (including but not restricted to bone spicule pigmentation, attenuation of the retinal vessels, and waxy pallor of the optic nerve).
Diagnosis of RCD is confirmed on prior full-field ERG (any previously performed ERG is acceptable).
Documented preservation of cone inner and outer segments considered good enough by the investigator for the subject to be included in the study.
Negative serum pregnancy test for women of childbearing potential (please refer to Schedule of Assessments for details).
Women of childbearing potential (WOCBP) and men and/or their partner(s) of childbearing potential must agree to use a highly effective contraceptive method. This applies to the time period between ICF signature and 12 months after SPVN06 subretinal injection SRI (i.e., no longer applicable to subjects of Cohort 4 after randomization). The definition of highly effective contraceptive methods follows CTFG recommendations. Highly effective contraceptive methods are limited to:
Combined (estrogen and progestogen containing) hormonal contraception associated with inhibition of ovulation:
Oral
Intravaginal
Transdermal
Progestogen-only hormonal contraception associated with inhibition of ovulation:
Oral
Injectable
Implantable
Intrauterine device (IUD)
Intrauterine hormone-releasing system (IUS)
Bilateral tubal occlusion
Vasectomized partner

You may not qualify if…

Subjects are not eligible to participate in this study if any of the following criteria apply:
Subjects with prior administration of any gene therapy or any previous treatment with stem cell therapy for ocular or non-ocular disease.
Subjects participating in another clinical trial and receiving an investigational medicinal product (IMP) within 5 half-lives or 90 days prior to the injection of SPVN06.
Subjects with systemic disease or other pathology not related to their diagnosis of RCD, and whose symptoms or associated treatments may affect vision, for example cancers or pathology of the central nervous system.
Subjects with narrow irido-corneal angles or any other medical situation contraindicating pupillary dilation.
Subjects known to be allergic to any of the delivery vehicle constituents or to any other drugs planned to be used during the clinical study.
Subjects with known allergies to corticosteroids, or who will be unable to tolerate the corticosteroid regimen as described in the protocol
Subjects with systemic disease or other medical or psychiatric conditions that preclude safe participation in the study.
Subjects receiving immunosuppressive therapies, other than the immune modulating regimen described in this protocol, or any other therapy known to influence the immune system including but not limited to steroid implants, cytostatics, interferons, tumor necrosis factor (TNF)-binding proteins, drugs acting on immunophilins, or antibodies with known impact on the immune system.
Subjects of reproductive potential unwilling to use effective contraception starting right after ICF signature and for 12 months after SPVN06 SRI (i.e., no longer applicable to subjects of Cohort 4 after randomization).
Subjects who are pregnant or breastfeeding.
Subjects who are unwilling or unable (based on the investigator's judgment) to comply with the study protocol.
Subjects with any condition that would not allow them to complete follow-up examinations during the study and, in the opinion of the investigator, would make them unsuitable for the study.
Subjects positive for human immunodeficiency virus (HIV) or any other systemic immunocompromising disease.
Subjects who have undergone, within 6 months before inclusion, any significant ocular surgery (per investigator's judgment) that could interfere with the evaluation of SPVN06 study objectives.
Presence of eye disorders that could interfere with the assessment of visual acuity and/or any other ocular assessments, including SD-OCT, during the study.
Presence of any systemic or ocular diseases, other than non-syndromic retinitis pigmentosa (RP), that can cause vision loss.
Prior full core vitrectomy or vitreomacular surgery in the Study Eye.
Presence of vitreomacular adhesion or traction, epiretinal membrane macular pucker or macular hole, evident by ophthalmoscopy and/or SD-OCT examinations and assessed by the investigator to significantly affect central vision.
Current evidence of retinal detachment assessed by the investigator to significantly affect central vision.
Active ocular inflammation or recurrent history of idiopathic or autoimmune-associated uveitis.
Subjects with presence of any suspected or active ocular or periocular infection (conjunctivitis, keratitis, scleritis, endophthalmitis).
Subjects with history of glaucoma.
Subjects with uncontrolled intraocular pressure (IOP).
Subjects with active cancer or currently receiving any therapy for cancer treatment.

Where it is running

Bascom Palmer Eye Institute/University of Miami — Miami, Florida, United States
Mass Eye and Ear — Boston, Massachusetts, United States
Casey Eye Institute — Portland, Oregon, United States
UPMC Eye Center — Pittsburgh, Pennsylvania, United States
Retina Foundation of the Southwest — Dallas, Texas, United States
CHNO XV-XX Paris - CIC 1423 — Paris, France

Full record on ClinicalTrials.gov

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