Acute Effects of Autoregulated and Non-autoregulated Blood Flow Restrictive Bicep Curls
Status unconfirmed · Not applicable
Conditions studied: Arterial Stiffness, Healthy Lifestyle
In brief
The purpose of this study is to investigate the acute effects of autoregulated (AR) and non-autoregulated (NAR) blood flow restriction (BFR) bicep curls on indices of arterial stiffness. We are attempting to differentiate physiological changes with AR and NAR bicep curl exercise. Twenty adults aged 18-40 years old will undergo three treatment sessions (control (no BFR), AR BFR and NAR BFR) in a randomized order separated by one week. A familiarization session will also occur one week before starting the treatment period. Each subject will undergo a series of tests including anthropometry, ultrasonography of the carotid artery, applanation tonometry, ultrasonography of the vastus lateralis, blood pressure acquisition, body composition, and maximal strength assessments (1RM). After a familiarization session with the BFR device, subjects will perform arm curls during the three treatment sessions with 4 sets to failure with a 2 seconds concentric and 2 seconds eccentric cadence, at 20% 1RM using 60% of the supine limb occlusion pressure (LOP) with 1-minute rest intervals. Assessments will be performed immediately before and after the exercise bout during each treatment session. Two-way ANOVAs will be used to examine the effects of treatment and the treatment-order interaction on pulse wave velocity, beta-stiffness index, and augmentation index.
Key facts
- Study ID
- NCT05748821
- Run by
- Salisbury University
- People needed
- 20
- Starts
- 2023-04-01
- Expected to finish
- 2023-12-20
- Last updated by the study team
- 2023-07-27
Who can join
Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age 18-40 years old
- Physically active (> 6 months of consistent exercise training)
- Weight stable for previous 6 months (+/-2.5 kg)
- Female subjects only- reported regular menstrual cycles for the last 2 years
You may not qualify if…
- BP>140/90 mmHg
- BMI>40 kg/m2
- Diabetes
- Familial hypercholesterolemia
- Past or current history of CHD, stroke or major CVD events. Respiratory diseases (not including asthma), endocrine or metabolic, neurological, or hematological disorders that would compromise the study or the health of the subject.
- Women must not be pregnant, plan to become pregnant during the study, or be nursing
- Active renal or liver disease
- All medications and supplements that influence dependent variables
- Recent surgery < 2 months
- Alcohol abuse
- Sleep apnea
- Claustrophobia
Where it is running
- Salisbury University — Salisbury, Maryland, United States (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.