Registry Study for Optimal Management of Liver Failure in the Chinese Population

Recruiting now

Conditions studied: Liver Failure

In brief

Liver failure is the most severe form of liver damage caused by viral, alcoholic, drug-related and ischemia-reperfusion factors, often combined with extrahepatic organ damage, resulting in a high mortality rate. This study intends to construct a real-world case registry database of inpatients with liver failure based on an electronic clinical data collection system through a multicenter collaborative network to study the clinical characteristics, epidemiology of bacterial and fungal infections, the impact of sarcopenia on clinical prognosis, and optimization of treatment strategies such as antiviral and artificial liver in Chinese inpatients with liver failure. The cohort and experience generated from this study will be used as a support for a series of future studies to focus on clinical issues such as infection, end-stage liver disease combined with organ failure, and early warning of critically ill patients.

Key facts

Study ID

NCT05740696

Run by

First Affiliated Hospital Xi'an Jiaotong University

People needed

500

Starts

2023-01-06

Expected to finish

2028-12-30

Last updated by the study team

2023-02-23

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with a diagnosis consistent with liver failure and pre-liver failure:
• Extreme weakness with significant gastrointestinal symptoms such as anorexia, vomiting and abdominal distention;
• Elevated alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST) with progressive jaundice (TBil≥85.5 μmol/L);
• Bleeding tendency with PTA ≤ 60% or INR ≥ 1.5.

You may not qualify if…

• An event or complication that, in the judgment of the investigator, significantly affects the assessment of clinical status.

Where it is running

• Ankang Central Hospital — Ankang, China (enrolling)
• Xianyang Central Hospital — Xianyang, China (enrolling)
• The Second Affiliated Hospital of Xi'an Jiaotong University — Xi'an, China (enrolling)
• First Affiliated Hospital of Xi'an Jiaotong University — Xi'an, Shaanxi, China (enrolling)
• First Hospital of Lanzhou University — Lanzhou, China
• Weinan Central Hospital — Weinan, China
• Air Force Medical University Tangdu Hospital — Xi'an, China
• Shaanxi provincial people's hospital — Xi'an, China
• Xi 'an International Medical Center Hospital — Xi'an, China
• The Affiliated Hospital of Yan'an University — Yanan, China
• General Hospital of Ningxia Medical University — Yinchuan, China
• Xiangya Hospital of Central South University — Changsha, China
• Hanzhong 3201 Hospital — Hanzhong, China
• Qilu Hospital of Shandong University — Jinan, China

Full record on ClinicalTrials.gov

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