Oral Immunotherapy for Egg Allergy in Children Aged 6 to 16

Recruiting now · Not applicable

Conditions studied: Egg Allergy

In brief

The aim of the study is to determine the efficacy of a 12-month egg oral immunotherapy (OIT) protocol with a cooked whole egg product including yolk and egg white. Study hypothesis: With this method the risk for severe allergic reaction to egg protein is reduced and the diet can partly or completely be normalized.

Key facts

Study ID

NCT05740163

Run by

Tampere University Hospital

People needed

60

Starts

2019-12-30

Expected to finish

2026-12-31

Last updated by the study team

2024-04-10

Who can join

Age: 6 and older, up to 16. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 6 to 16 years
• Elevated spesific serum IgE to egg (> 5 kU/l) and/or positive skin prick to egg allergen
• Positive oral food challenge for egg or anaphylaxis reaction to egg within the 6 months
• Diet free from egg in any form

You may not qualify if…

• Age less than 6 years or more than 16 years
• Poor asthma control or uncontrolled asthma
• Severe/significant cardiovascular disease
• Autoimmune disease
• Malignancy
• Medication: beta bloker, angiotensin-converting-enzyme inhibitors (ACE inhibitors), Monoamine oxidase inhibitors (MAOIs)
• Poor compliance
• Fear of immunotherapy
• Desensitization to alfa-gal-protein (mammalian meat allergy)

Where it is running

• Oulu University Hospital — Oulu, Finland (enrolling)
• Tampere University Hospital — Tampere, Finland (enrolling)

Full record on ClinicalTrials.gov

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