Dose Finding Study of [177Lu]Lu-NeoB in Newly Diagnosed Glioblastoma and in Recurrent Glioblastoma
Running, not enrolling · Phase 1
Conditions studied: Newly Diagnosed and Recurrent Glioblastoma
In brief
This study will investigate different doses of \[177Lu\]Lu-NeoB in combination with RT and TMZ in participants with newly diagnosed glioblastoma, with methylated or unmethylated promoter, to assess the safety and efficacy of \[177Lu\]Lu-NeoB in combination with the SoC and in recurrent glioblastoma as single agent, to identify the recommended dose and to also explore the safety of the PET imaging agent \[68Ga\]Ga-NeoB and characterize its uptake in the tumor area.
Key facts
- Study ID
- NCT05739942
- Run by
- Novartis Pharmaceuticals
- People needed
- 42
- Starts
- 2024-05-15
- Expected to finish
- 2028-11-08
- Last updated by the study team
- 2026-05-14
Who can join
Age: 18 and older, up to 100. Sex: any. Healthy volunteers: not accepted.
Where it is running
- University of California LA — Los Angeles, California, United States
- University of Colorado Denver — Aurora, Colorado, United States
- Dana Farber Cancer Institute — Boston, Massachusetts, United States
- Memorial Sloan Kettering Cancer Ctr — New York, New York, United States
- Univ Hosp Cleveland Medical Center — Cleveland, Ohio, United States
- Uni of Utah Huntsman Cancer Inst — Salt Lake City, Utah, United States
- Novartis Investigative Site — Dijon, Cote D Or, France
- Novartis Investigative Site — Essen, Germany
- Novartis Investigative Site — München, Germany
- Novartis Investigative Site — Reggio Emilia, RE, Italy
- Novartis Investigative Site — Porto, Portugal
- Novartis Investigative Site — Granada, Andalusia, Spain
- Novartis Investigative Site — Badalona, Barcelona, Spain
- Novartis Investigative Site — L'Hospitalet de Llobregat, Barcelona, Spain
- Novartis Investigative Site — Madrid, Spain
- Novartis Investigative Site — Madrid, Spain
Full record on ClinicalTrials.gov
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