Whole Genome Sequencing (WGS) on IVF Embryos and Individual Patients

Status unconfirmed

Conditions studied: Fertility Issues, Single-Gene Defects

In brief

This research project aims to utilise recent advances in whole genome sequencing of preimplantation genetic diagnosis embryos to investigate the impact of paternal age on de novo mutation rates in IVF embryos. Embryos that are deemed unsuitable for transfer following preimplantation genetic testing for monogenic/single gene disorders (PGT-M) due to the detection of genetic abnormalities will be utilized for this study. These embryos will undergo re-biopsy, and both the biopsied samples as well as the remaining embryo tissue will be subject to whole genome sequencing. This will allow the assessment of de novo mutation rates based on the paternal age.

Key facts

Study ID

NCT05739890

Run by

GenEmbryomics Pty. Ltd

People needed

100

Starts

2023-06-01

Expected to finish

2024-08-01

Last updated by the study team

2023-09-25

Who can join

Age: 18 and older, up to 48. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

• Female patients with low ovarian reserve (< 10 follicles or FSH>10, AMH <1).

Where it is running

• Preimplantation Genetic Testing Unit ART and Reproductive Genetics Unit, Memorial Sisli Hospital — Istanbul, Okmeydani-Sisli, Turkey (Türkiye) (enrolling)
• Neway Fertility — New York, New York, United States
• ORM Fertility — Portland, Oregon, United States
• Poma Fertility — Kirkland, Washington, United States

Full record on ClinicalTrials.gov

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