Comparison of Two Sedation Regimens for Awake Fiberoptic Intubation

Recruiting now

Conditions studied: Awake Fiberoptic Intubation, Difficult Airway

In brief

The purpose of this study is to examine the effects of different sedation drugs used for the awake fiberoptic intubation procedure. Benzodiazapines and narcotics (such as midazolam and fentanyl) are standard drugs used for sedation during awake fiberoptic intubation. Dexmedetomidine, midazolam, and fentanyl are approved by the Food and Drug Administration (FDA) procedural sedation. These drugs might be given to the patient regardless of their participation in the study. In addition to midazolam and fentanyl study subjects will also receive either dexmedetomidine or a placebo (a salt solution that contains no drug). It is believed that dexmedetomidine will not slow down breathing as much as the combination of the valium-like drug and narcotic. In our study, we are trying to determine if this is the best drug for sedation during an awake fiberoptic procedure.

Key facts

Study ID

NCT05736198

Run by

University of Illinois at Chicago

People needed

96

Starts

2024-08-12

Expected to finish

2034-03-01

Last updated by the study team

2024-11-29

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects with potentially difficult airways who require awake fiberoptic intubations will be identified from the OR schedule and the pre-operative clinic workups.

You may not qualify if…

• Anyone who does not meet the inclusion criteria

Where it is running

• University of Illinois — Chicago, Illinois, United States (enrolling)

Full record on ClinicalTrials.gov

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