Longitudinal Study for Central Nervous System Vasculitis

Recruiting now

Conditions studied: Central Nervous System Vasculitis, CNS Vasculitis, CNSV, Vasculitis

In brief

Primary central nervous system vasculitis (CNSV) is a potentially fatal, single-organ vasculitis that often involves a spectrum of neurologic complications, including strokes, cognitive and speech impairment, visual loss, dementia, and encephalopathy. The purpose of this study is to establish a research cohort to investigate the disease process, treatments, and patient outcomes in CNSV.

Key facts

Study ID

NCT05734404

Run by

University of Pennsylvania

People needed

40

Starts

2023-03-01

Expected to finish

2030-12-31

Last updated by the study team

2026-01-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• i. Diagnostic criteria for CNSV
• The presence of an acquired and otherwise unexplained neurologic deficit
• The presence of either classic angiographic or histopathologic features of angiitis in the CNS
• No evidence of systemic vasculitis or any condition that could cause the angiographic or pathologic features
• ii. ≥18 years of age

You may not qualify if…

• i. Unwilling to sign informed consent.

Where it is running

• Mayo Clinic — Rochester, Minnesota, United States (enrolling)
• Cleveland Clinic — Cleveland, Ohio, United States (enrolling)
• University of Pennsylvania — Philadelphia, Pennsylvania, United States (enrolling)
• Vanderbilt University — Nashville, Tennessee, United States (enrolling)
• St. Joseph's Healthcare — Hamilton, Canada (enrolling)
• University of Toronto/Sinai Health — Toronto, Canada (enrolling)

Full record on ClinicalTrials.gov

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