Prognosis of Cerebral Small Vessel Disease

Recruiting now

Conditions studied: Cerebral Amyloid Angiopathy, Small Vessel Cerebrovascular Disease, Cadasil, CAA - Cerebral Amyloid Angiopathy

In brief

Prognosis of small vessel disease (SVD) depends on the underlying type of SVD and index manifestation. The aim of this prospective, observational cohort study is to determine the risk of different outcome events among patients with SVD according to the type of index presentation.

Key facts

Study ID

NCT05734378

Run by

Insel Gruppe AG, University Hospital Bern

People needed

900

Starts

2020-12-01

Expected to finish

2030-11-30

Last updated by the study team

2023-03-08

Who can join

Age: 16 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Hypertensive deep perforator arteriolopathy (DPA), clinically symptomatic with either ICH, ischaemic stroke, cognitive impairment or severe radiological manifestation (Fazekas ≥II)
• Cerebral amyloid angiopathy (CAA according to modified Boston or Edinburgh criteria), clinically symptomatic with either ICH (including cSAH), amyloid spells, cognitive impairment or severe radiological manifestation (CMB≥2)
• Other SVD (i.e. CADASIL or other sporadic or genetic SVD)

You may not qualify if…

• Life expectancy of <6 months due to not-SVD related causes (i.e. cancer)
• Patient is unlikely to attend follow-up visits

Where it is running

• Department of Neurology, Inselspital Bern University Hospital — Bern, Switzerland (enrolling)

Full record on ClinicalTrials.gov

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