UVB-Induced MVP Release in Human Skin

Completed · Phase 1

Conditions studied: Ultraviolet B Radiation, Microvesicle Particles

In brief

This study is designed to assess if ultraviolet B radiation (UVB) found in sunlight causes the release of microvesicle particles in human skin, and if antioxidant vitamins can block their production.

Key facts

Study ID

NCT05734235

Run by

Wright State University

People needed

8

Starts

2018-07-16

Expected to finish

2022-10-26

Last updated by the study team

2023-02-24

Who can join

Age: 21 and older, up to 45. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Male subjects
• Ages 21 to 45
• Skin type: Fitzpatrick Type I or II

You may not qualify if…

• Have underlying diseases that could affect wound healing
• On medications that are known photosensitizers (e.g., doxycycline) or anti-inflammatories (e.g., NSAIDS [except for low-dose aspirin] or steroids)
• History of abnormal scarring (e.g., keloids)
• Should not be on Vitamin C or E supplements for past month
• Unable to understand/complete informed consent
• Large volar arm tattoos that would inhibit the ability to conduct/evaluate the skin testing
• Renal compromise/kidney stones or allergy to Vitamin C/Vitamin E or lidocaine anaesthetic
• Use of tanning bends or recent UVB exposure to the areas in the past 3 months
• Recent (within 1 week) use to sunscreen to volar forearms

Where it is running

• Wright State Physicians — Fairborn, Ohio, United States

Full record on ClinicalTrials.gov

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