Study of RP2 in Combination With Second-line Therapy in Patients With Locally Advanced or Metastatic HCC
Recruiting now · Phase 2
Conditions studied: Hepatocellular Carcinoma, Biliary Tract Cancer
In brief
The purpose of this study is to assess the efficacy and safety of RP2 in combination with atezolizumab plus bevacizumab (Cohorts 1a and 1b) and RP2 monotherapy (Cohort 2) in the as second line treatment in patients with locally advanced unresectable, recurrent, and/or metastatic HCC and in combination with durvalumab as treatment in patients with unresectable locally advanced or metastatic BTC.
Key facts
- Study ID
- NCT05733598
- Run by
- Replimune, Inc.
- People needed
- 60
- Starts
- 2024-08-01
- Expected to finish
- 2028-07-01
- Last updated by the study team
- 2026-04-02
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Beverly Hills Cancer Center — Beverly Hills, California, United States (enrolling)
- UC San Diego Moores Cancer Center — La Jolla, California, United States (enrolling)
- Sylvester Comprehensive Cancer Center (University of Miami Hospital and Clinics) — Miami, Florida, United States (enrolling)
- Moffitt Cancer Center — Tampa, Florida, United States (enrolling)
- University of Maryland Medical Center — Baltimore, Maryland, United States (enrolling)
- Roswell Park Comprehensive Cancer Center — Buffalo, New York, United States (enrolling)
- Montefiore Medical CenterMontefiore Medical Park — The Bronx, New York, United States (enrolling)
- University of Pennsylvania, Abramson Cancer Center — Philadelphia, Pennsylvania, United States (enrolling)
- UPMC Hillman Cancer Center — Pittsburgh, Pennsylvania, United States (enrolling)
- The West Clinic — Germantown, Tennessee, United States (enrolling)
- University of Tennessee Medical Center — Knoxville, Tennessee, United States (enrolling)
- Houston Methodist Hospital Cancer Center — Houston, Texas, United States (enrolling)
Full record on ClinicalTrials.gov
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