Counseling for Harm Reduction and Retention in Medication-assisted Treatment - Cherokee Nation

Running, not enrolling · Not applicable

Conditions studied: Opioid Use Disorder

In brief

The goal of this randomized clinical trial is to test the efficacy of a program meant to enhance Counseling for Harm Reduction and Retention in MAT in Cherokee Nation (CHaRRM-CN). The main questions it aims to answer are whether CHaRRM-CN: improves retention of patients in MAT, decreases substance-related harm and illicit opioid use, and increases cultural connectedness. After providing written, informed consent, participants will attend a baseline assessement and will then be randomized to either the CHaRRM-CN or treatment as usual group. For 6 months after randomization, participants will be exposed to CHaRRM-CN or treatment as usual. During that time, participants will also attend the 1-month, 3-month and 6-month follow-ups to track their progress through the programs. After the 6 months of either treatment condition, investigators will compare the groups to see if they differ on retention, substance-use outcomes and Native enculturation.

Key facts

Study ID: NCT05733442
Run by: Washington State University
People needed: 136
Starts: 2023-01-17
Expected to finish: 2026-07-31
Last updated by the study team: 2026-05-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

At least 18 years of age
Must be newly registered (within 4 weeks) in the CNHS MAT Program. (Prior patients can participate as long as their most recent treatment course was at least 6 months prior).
Must be willing to provide written informed consent to enroll in this study

You may not qualify if…

Refusal or inability to consent to participation in research. (The latter is assessed using the UCSD Brief Assessment of Capacity to Consent.)
Refusal or inability to consent and constituting a risk to the safety and security of other patients or staff

Where it is running

Cherokee Nation Health Services — Tahlequah, Oklahoma, United States
University of Washington School of Medicine — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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