Improving Smoking Abstinence Outcomes in the African American Community Through Extended Treatment
Recruiting now · Phase 3
Conditions studied: Smoking Cessation
In brief
This study will evaluate the efficacy of extended bupropion(6 months) versus standard bupropion treatment (7 weeks) among African American daily smokers.
Key facts
- Study ID
- NCT05732272
- Run by
- University of Kansas Medical Center
- People needed
- 500
- Starts
- 2023-02-28
- Expected to finish
- 2027-04-30
- Last updated by the study team
- 2026-02-23
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- African American
- age >18 years
- interested in quitting
- smoked >1 cpd for >1 years
- smoked on >25 days in the past month
- willing to take 6 months of study medication and complete all visits
- have a home address and functioning telephone number
You may not qualify if…
- Consistent with contraindications for bupropion:
- use of psychoactive medications
- history of alcohol or substance abuse within the past year
- binge drinking (>5 drinks on one occasion) >2 times in the past month
- history of seizures or head trauma; history of bulimia or anorexia nervosa
- pregnant (as measured by over the counter pregnancy test kit for women of child-bearing age only) or contemplating pregnancy; breast feeding
- myocardial infarction in the past 2 months
- reported use of opiates, cocaine, or stimulants
- unstable diabetes
- bupropion is a known inhibitor of the liver enzyme CYP2D6, so those taking drugs known to be higher metabolized by this enzyme (e.g., metoprolol, tamoxifen) will be excluded.
- use of stop smoking medications (bupropion, varenicline, nicotine replacement, fluoxetine, clonidine, buspirone, or doxepin) in the past 30 days
- planning to move from the Kansas City area in the next year
- other smoker in household enrolled in the study.
Where it is running
- University of Kansas Medical Center — Kansas City, Missouri, United States (enrolling)
Full record on ClinicalTrials.gov
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