A Study of Teropavimab and Zinlirvimab in Combination With Capsid Inhibitor Lenacapavir in Virologically Suppressed Adults With HIV-1 Infection
Running, not enrolling · Phase 2
Conditions studied: HIV-1 Infection
In brief
The goal of this study is to test the effectiveness, safety, and tolerability of the combination of broadly neutralizing antibodies (bNAbs) (teropavimab (TAB; GS-5423) and zinlirvimab (ZAB; GS-2872)) with lenacapavir (LEN) in virologically suppressed adults with HIV-1 infection. The purpose of this study is to evaluate the efficacy of switching to a regimen of LEN, TAB and ZAB, versus continuing on baseline oral antiretroviral therapy (ART) as determined by the proportion of participants with human immunodeficiency virus-1 (HIV-1) ribonucleic acid (RNA) ≥ 50 copies/mL at Week 26.
Key facts
- Study ID
- NCT05729568
- Run by
- Gilead Sciences
- People needed
- 83
- Starts
- 2023-05-15
- Expected to finish
- 2030-12-01
- Last updated by the study team
- 2026-04-27
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Ruane Clinical Research Group, Inc. — Los Angeles, California, United States
- Mills Clinical Research — Los Angeles, California, United States
- UC San Diego (UCSD) AntiViral Research Center (AVRC) — San Diego, California, United States
- Optimus Medical Group — San Francisco, California, United States
- University of Colorado Clinical and Translational Research Center — Aurora, Colorado, United States
- Yale University; School of Medicine; AIDS Program — New Haven, Connecticut, United States
- Georgetown University Medical Center — Washington D.C., District of Columbia, United States
- Midland Florida Clinical Research Center, LLC — DeLand, Florida, United States
- Can Community Health Care — Fort Lauderdale, Florida, United States
- Midway Immunology and Research Center — Ft. Pierce, Florida, United States
- Orlando Immunology Center — Orlando, Florida, United States
- Triple O Research Institute, P.A. — West Palm Beach, Florida, United States
- Emory University Hospital Midtown Infectious Disease Clinic — Atlanta, Georgia, United States
- Infectious Disease Specialists of Atlanta — Decatur, Georgia, United States
- Southhampton Healthcare, Inc — St Louis, Missouri, United States
- AXCES Research Group, LLC — Albuquerque, New Mexico, United States
- Montefiore Medical Center — The Bronx, New York, United States
- NC TraCS Institute - CTRC; University of North Carolina at Chapel Hill — Chapel Hill, North Carolina, United States
- Duke University Health Center — Durham, North Carolina, United States
- Regional Center for Infectious Disease Research — Greensboro, North Carolina, United States
- The Brody School of Medicine at East Carolina University — Greenville, North Carolina, United States
- Rosedale Health and Wellness — Huntersville, North Carolina, United States
- Prisma Health - Clinical Research Unit — Columbia, South Carolina, United States
- St Jude Children's Research Hospital — Memphis, Tennessee, United States
- Central Texas Clinical Research — Austin, Texas, United States
Full record on ClinicalTrials.gov
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