Cohort of Twin Pregnancy and the Offspring

Recruiting now

Conditions studied: Twin Pregnancy

In brief

Twin pregnancy increases the risk of maternal and fetal complications, which include gestational hypertension, premature labor, twin-to-twin transfusion syndrome, intrauterine growth restriction, anemia, amniotic fluid abnormalities. Comprehensively understanding the molecular mechanisms of the disease and identification of markers contribute to development of novel therapeutic approaches. In addition, the twin pregnancy, especially the monochorionic, is an essential model of "experiments of nature". This model can be applied to distinguish the epigenetic differences of twins in utero and after birth in the same genomic context. The aim of the study is to constitute a prospective cohort of twin pregnancies and the offspring.

Key facts

Study ID

NCT05727085

Run by

Fudan University

People needed

1000

Starts

2023-10-15

Expected to finish

2029-06-15

Last updated by the study team

2025-03-14

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Maternal age >18 years old.
• Twin pregnancy.

You may not qualify if…

• Fetal chromosomal or congenital abnormalities.
• Stillbirth.

Where it is running

• Obstetrics and Gynecology Hospital of Fudan University — Shanghai, Shanghai Municipality, China (enrolling)

Full record on ClinicalTrials.gov

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