A Research Study on How Well Semaglutide Helps Children and Teenagers With Excess Body Weight Lose Weight

Running, not enrolling · Phase 3 · Has a placebo group

Conditions studied: Obesity

In brief

This study will look at how well semaglutide helps children and teenagers losing weight. This will be tested by comparing the effect on body weight in children and teenagers taking semaglutide in comparison to placebo, a "dummy" medicine. In addition to taking the medicine, the child's parent and the child will have talks with study staff about healthy food choices, how to be more physically active and what your child can do to try to lose weight. The child will either get semaglutide or a "dummy" medicine. Which treatment the child will get is decided by chance. Semaglutide is an approved medicine for type 2 diabetes and weight management in adults. The child will get one injection once a week. The study medicine is injected with a thin needle in the stomach, thighs or upper arms. The study will last for about 2 ½ years (132 weeks).

Key facts

Study ID

NCT05726227

Run by

Novo Nordisk A/S

People needed

210

Starts

2023-07-07

Expected to finish

2026-12-07

Last updated by the study team

2026-08-07

Who can join

Age: 6 and older, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Informed consent of parent(s) or legally acceptable representative (LAR) of participant and child assent, as age-appropriate, obtained before any study-related activities. Study-related activities are any procedures that are carried out as part of the study, including activities to determine suitability for the study. a) The parents or LAR of the child must sign and date the Informed Consent Form (according to local requirements) b) The child must sign and date the Child Assent Form or provide oral assent (according to local requirements)
• Age at the time of signing informed consent. a)Group Kids: 6 to less than 12 years. b) Group Teens: 12 to less than 18 years and Tanner stage greater than 1
• Body mass index (BMI), at screening and randomisation, corresponding to a) Group Kids: greater than or equal to 95th percentile. b) Group Teens: greater than or equal to 95th percentile or greater than or equal to 85th percentile with the presence of at least 1 weight-related comorbidity (treated or untreated): hypertension, dyslipidaemia, obstructive sleep apnoea or type 2 diabetes mellitus (T2D)
• History of at least one unsuccessful effort to lose sufficient body weight after participation in a structured lifestyle modification programme (diet and exercise counselling) for at least 3 months
• Body weight of greater than 45 kilogram (kg) at screening and randomisation
• For participants with T2D at screening, the following additional criterion applies: glycated haemoglobin (HbA1c) less than or equal to 10.0 percent (86 millimoles per mole [mmol/mol]) as measured by central laboratory at screening

You may not qualify if…

• Treatment with any medication prescribed for the indication of obesity or weight management within 90 days before screening
• Previous or planned (during the study period) obesity treatment with surgery or a weight loss device. However, the following are allowed: a) liposuction and/or abdominoplasty, if performed greater than 1 year prior to screening. b) adjustable gastric banding, if the band has been removed greater than 1 year prior to screening. c) intragastric balloon, if the balloon has been removed greater than 1 year prior to screening. d)duodenal-jejunal bypass liner (e.g., nonbarrier), if the sleeve has been removed greater than 1 year prior to screening
• Type 1 diabetes mellitus or monogenic diabetes
• Participants with endocrine, hypothalamic, or syndromic obesity
• For participants with T2D at screening, the following additional key criterion applies: Uncontrolled and potentially unstable diabetic retinopathy or maculopathy. Verified by a fundus examination performed within the past 90 days before screening or in the period between screening and randomisation. Pharmacological pupil-dilation is a requirement unless using a digital fundus photography camera specified for non-dilated examination

Where it is running

• Yale School of Medicine — New Haven, Connecticut, United States
• Columbus Research Foundation — Columbus, Georgia, United States
• Eastside Bariatric and Gen Surg — Snellville, Georgia, United States
• Solaris Clinical Research — Meridian, Idaho, United States
• Pennington Biom Res Ctr — Baton Rouge, Louisiana, United States
• Clinical Trials of America LLC — Monroe, Louisiana, United States
• IMA Clinical Research — Monroe, Louisiana, United States
• Barry J. Reiner, MD LLC — Baltimore, Maryland, United States
• Massachusetts General Hospital_Cary — Boston, Massachusetts, United States
• University of Minnesota — Minneapolis, Minnesota, United States
• Mississippi Center for Advanced Medicine — Madison, Mississippi, United States
• Mississippi CTR for ADV MED — Madison, Mississippi, United States
• UBMD Peds-Div of Endo/Diabetes — Buffalo, New York, United States
• WakeMed Childn Endo-Dbt_Raleig — Raleigh, North Carolina, United States
• Valley Weight Loss Clinic — Fargo, North Dakota, United States
• Centricity Research - Ohio — Columbus, Ohio, United States
• UPMC Child Hosp-Pittsburgh — Pittsburgh, Pennsylvania, United States
• Vanderbilt University Medical Center — Nashville, Tennessee, United States
• Pediatric Clinical Trials, LLC — Tullahoma, Tennessee, United States
• Texas Diabetes & Endocrinology — Austin, Texas, United States
• Univ Of Texas Hlth Science Cntr — San Antonio, Texas, United States
• Health Res of Hampton Roads — Newport News, Virginia, United States
• Marshfield Clinic — Marshfield, Wisconsin, United States
• Universitätsklinik Kinder-Jugendheilkunde Innsbruck — Innsbruck, Austria
• Neighborhood Healthcare — Escondido, California, United States

Full record on ClinicalTrials.gov

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