Fluid Challenge and Plasma Volume, During Surgery

Recruiting now · Phase 4

Conditions studied: Colorectal Cancer, Urologic Cancer, Gynecologic Cancer, Colorectal Disorders, Benign Neoplasm

In brief

A short bolus infusion of fluid, called "fluid challenge" is commonly recommended for fluid treatment during longer surgery. However a prolonged increase of the blood volume is a prerequisite to recommend the technique. The purpose with the study is to examine the plasma expanding effect of three different fluid challenge strategies (acetated Ringers 4 ml/kg body weight, albumin 5% 4 ml/kg body weight or albumin 20% 1 ml/kg body weight), using hemoglobin as a dilution indicator.

Key facts

Study ID

NCT05726136

Run by

Joachim Zdolsek

People needed

60

Starts

2023-10-23

Expected to finish

2026-10-31

Last updated by the study team

2026-04-30

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Written consent to participate in the study
• For women: relevant contraceptive, menopausal or a negative pregnancy test.
• ASA category I to III
• Laparoscopic abdominal surgery, with a duration of at least 90 minutes.
• 18 to 85 years

You may not qualify if…

• Patients with known cardiac failure
• <18 or >85 years
• known allergy to albumin
• extracellular hyperhydration or hypervolemia
• kidney failure
• pregnancy or planned pregnancy

Where it is running

• Vrinnevi Hospital — Norrköping, Östergötland County, Sweden (enrolling)

Full record on ClinicalTrials.gov

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