Ocular Blood Flow Imaging for Glaucoma Assessment

Recruiting now · Not applicable

Conditions studied: Glaucoma

In brief

The goal of this clinical trial is to investigate the use of an FDA-cleared retinal blood flow imaging instrument called the XyCAM RI and XyCAM FC (Vasoptic Medical, Inc., Columbia, MD) in glaucoma management. The main question it aims to answer are: * Can the investigators use blood flow to discriminate between eyes with early-stage glaucoma and variable-matched controls? * Can the investigators validate that the XyCAM FC simultaneously captures both stereo fundus photography and ocular blood flow monitoring? Participants will be * measured for their blood pressure, heart rate, height, and weight * dilated with tropicamide * imaged using the XyCAM RI, fundus photography, optical coherence tomography, and standard automated perimetry * imaged using the XyCAM RI while inhaling 100% oxygen through a mask

Key facts

Study ID

NCT05726058

Run by

University of Maryland, Baltimore

People needed

150

Starts

2023-03-30

Expected to finish

2028-04-30

Last updated by the study team

2026-07-02

Who can join

Age: 18 and older, up to 88. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 18 and older with binocular vision
• Able to provide informed consent
• Patient is a healthy control OR is recommended for glaucoma assessment OR diagnosed with moderate to severe glaucoma in at least one eye as determined by Hodapp Anderson Criteria

You may not qualify if…

• The subject has significant media opacity (e.g., a visually significant cataract or significant corneal scar)
• The subject has previous ocular surgery other than uncomplicated cataract extraction, laser trabeculoplasty (ALT or SLT), or YAG capsulotomy
• The subject has prior ocular disease other than glaucoma
• The subject has anatomically narrow angles or a prior adverse reaction to administration of Tropicamide or fluorescein dye
• The subject has more than 15 diopters of refractive error
• The subject is a female who is pregnant or nursing
• The subject has diabetes mellitus

Where it is running

• University of Maryland Eye Associates at Redwood — Baltimore, Maryland, United States (enrolling)

Full record on ClinicalTrials.gov

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