Arterial Spin Labeling MRI for Assessing Blood Perfusion in the Human Eye Repeatability Study and Clinical Application

Recruiting now · Not applicable

Conditions studied: Retinal Diseases

In brief

The MRI perfusion imaging using arterial spin labeling (ASL)'s non-invasive technique (i.e. without injection of contrast medium) allows, thanks to recent technological improvement of the spatial resolution, measuring several perfusion parameter of the retinal tissue such as the regional Blood Flow (rBF) or the cerebral blood flow (cBF) expressed in ml/100g/min. Reliable application of ASL thus requires the precision and specificity of the MRI protocol to be tested.

Key facts

Study ID

NCT05724641

Run by

Cliniques universitaires Saint-Luc- Université Catholique de Louvain

People needed

70

Starts

2023-01-10

Expected to finish

2026-06-30

Last updated by the study team

2025-05-16

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Carrier of target pathologies: TAO optic neuropathy, inflammatory optic neuropathy, ischemic optic neuropathy.
• no cardiovascular risk factors or other ophthalmological pathology
• adhere to the study protocol after reading the patient information document
• signe the informed consent form to participate in the study
• do not have any contraindications to an MRI examination

You may not qualify if…

• Usual contraindications to MRI (Pacemaker, Metallic foreign body, Cochlear implant,…)
• Severe claustrophobia

Where it is running

• Cliniques Universitaires Saint Luc — Brussels, Brussels Capital, Belgium (enrolling)

Full record on ClinicalTrials.gov

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