A Technology-Driven Intervention to Improve Early Detection and Management of Cognitive Impairment

Completed · Not applicable

Conditions studied: Dementia, Cognitive Impairment

In brief

Most experts advocate for early detection of cognitive impairment (CI) so that patients and caregivers can be prepared for making difficult decisions and to improve quality of life, but studies show that screening alone isn't sufficient to change clinician actions related to early detection. Using predictive modelling developed with machine learning methods and sophisticated clinical decision support (CDS) tools, it is possible to identify patients at elevated risk for CI and make it much easier for primary care to engage and support patients and caregivers in meaningful care planning. The goal of this study is to implement and evaluate a low-cost, highly scalable CI-CDS system integrated within the electronic health record that has high potential to improve early CI detection and care and translate massive public and private sector investments in health informatics into tangible health benefits for large numbers of people.

Key facts

Study ID

NCT05723523

Run by

HealthPartners Institute

People needed

3230

Starts

2023-08-23

Expected to finish

2025-09-30

Last updated by the study team

2025-11-04

Who can join

Age: 65 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Primary care office visit at a randomized clinic during the accrual period, AND
• Patient is age 65 or over, AND
• Patient has no CI diagnosis documented in the EHR prior to the visit, AND
• Patient has:
• Any abnormal score on a comprehensive cognitive assessment (MoCA, MMSE or SLUMS) in the prior 18 months, OR
• a MiniCog score of <3 in the prior 18 months and there is no evidence of subsequent comprehensive cognitive assessment (MoCA, MMSE, SLUMS), OR
• No cognitive testing in the last 18 months and a risk of a dementia diagnosis in the next 3 years >=15% as calculated by the MC-PLUS algorithm developed in the R61 phase
• AND
• First visit during the accrual period at which all prior inclusion criteria are met

You may not qualify if…

• Patient has received active parenteral chemotherapy within the last year
• Patient has stage 4 or equivalent cancer diagnosis
• Patient is enrolled in hospice care or palliative care program

Where it is running

• HealthPartners — Bloomington, Minnesota, United States
• OCHIN, Inc. — Portland, Oregon, United States

Full record on ClinicalTrials.gov

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