L-Citrulline and Endothelial Function

Completed · Phase 1

Conditions studied: Aging

In brief

The effect of L-Citrulline is well studied in relation to muscle strength, exhaustion, exercise performance, and endothelial function in health and disease. This study will extend current body of knowledge and will investigate the effect of L-Citrulline on brain vascular function.

Key facts

Study ID

NCT05722860

Run by

University of Oklahoma

People needed

20

Starts

2024-01-03

Expected to finish

2024-12-28

Last updated by the study team

2026-03-12

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 21-45 and ≥55-90 years of age
• Adequate hearing and visual acuity to participate in the examinations
• Ability to read and write in English
• Competence to provide informed consent

You may not qualify if…

• Active CNS disease including multiple sclerosis, uncontrolled seizures, active brain cancer
• Cerebrovascular accident other than TIA within 60 days prior to Visit 0
• Major psychiatric disease, including major depression not currently controlled on medications, alcohol or drug abuse
• Treatment with other Citrulline enhancers (L-Arginine, L-Citrulline Malate) within 4 weeks prior to Visit 0
• Any other medical condition which, in the opinion of investigator, would render the patient inappropriate or too unstable to complete the study protocol

Where it is running

• Andriy Yabluchanskiy — Oklahoma City, Oklahoma, United States

Full record on ClinicalTrials.gov

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