Trial of PRO1160 (GEN1160) in Relapsed or Refractory Non-Hodgkin Lymphoma (NHL) (PRO1160-001)
Stopped early · Phase 1/Phase 2
Conditions studied: Renal Cell Carcinoma, Nasopharyngeal Carcinoma, Non Hodgkin Lymphoma
In brief
Brief Summary: This study will test the safety, including side effects, and determine the characteristics of a drug called GEN1160 (PRO1160) in participants with solid tumors and blood cancers. Participants will have cancer that has spread through the body (metastatic) or cannot be removed with surgery (unresectable) or relapsed or refractory to prior treatments. This Phase 1/2 study will have three parts. The dose escalation part of the study will find out how much and how frequently GEN1160 should be given to participants. The expansion Part A and expansion Part B will use the dose and schedule found in the dose escalation part to find out how safe GEN1160 is and if it works to treat the diseases under study. The diseases under study will be Renal Cell Carcinoma (RCC), Nasopharyngeal Carcinoma (NPC) and Non-Hodgkin Lymphoma (NHL) in Escalation and diffuse large B-cell lymphoma (DLBCL) in expansion Part A and Part B.
Key facts
- Study ID
- NCT05721222
- Run by
- Genmab
- People needed
- 42
- Starts
- 2023-03-15
- Expected to finish
- 2025-11-05
- Last updated by the study team
- 2026-03-04
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Sarah Cannon Research Institute - Nashville — Nashville, Tennessee, United States
- City of Hope Comprehensive Cancer Center - Duarte — Duarte, California, United States
- The City of Hope Orange County Lennar Foundation Cancer Center — Irvine, California, United States
- University of Michigan — Ann Arbor, Michigan, United States
- Karmanos Cancer Institute — Detroit, Michigan, United States
- Washington University School of Medicine in St. Louis — St Louis, Missouri, United States
- NYU Langone Health — New York, New York, United States
- Montefiore Medical Center - Montefiore Hospital — The Bronx, New York, United States
- Levine Cancer Center — Charlotte, North Carolina, United States
- Cleveland Clinic - Euclid Hospital — Cleveland, Ohio, United States
- Providence Portland Medical Center — Portland, Oregon, United States
- Oregon Health & Science University — Portland, Oregon, United States
- MD Anderson Cancer Center — Houston, Texas, United States
- START Mountain Cancer Center — West Valley City, Utah, United States
- Cancer Hospital of Chinese Academy of Medical Sciences — Beijing, Beijing Municipality, China
- Fudan University Shanghai Cancer Center — Shanghai, Shanghai Municipality, China
- Ruijin Hospital, Shanghai Jiao Tong University School of Medicine — Shanghai, Shanghai Municipality, China
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.